Application Question
Hard difficulty • Concept in a practical situation
Question 1
Applied ConceptA patient's blood test shows a very low GFR. With reference to the JGA, explain the cascade of events that the body initiates to restore normal GFR.
- A low GFR is detected by the JG (juxtaglomerular) cells located at the junction of the DCT and afferent arteriole, which form the JGA.
- JG cells respond by releasing renin, which converts angiotensinogen in the blood to angiotensin I, and subsequently to angiotensin II.
- Angiotensin II acts as a potent vasoconstrictor, increasing glomerular blood pressure to restore GFR; it also triggers aldosterone release from the adrenal cortex.
- Aldosterone promotes Na+ and water reabsorption from the distal tubule, increasing blood volume and pressure, further supporting GFR restoration through the renin-angiotensin mechanism.